William Mather

Postdoctoral Fellow
wmather@ucsd.edu
(858) 822-3858

Research Interests

Drawing from a theoretical Physics background, my postdoc has primarily focused on the theoretical analysis of protein interaction networks and gene circuits. I am especially interested in the study of nonlinear response characteristics and delayed interactions in the context of stochastic models. A recurring theme in this research is the development of design principles for synthetic networks. I have also gained some experience with the design and implementation microfluidic devices, culminating in the synthesis of a device that applies a spatiotemporal signal across a bed of cells.

Publications

(submitted) Mather, W.H., Hasty, J., Tsimring, L.S. Fast stochastic algorithm for simulating evolutionary population dynamics.

[11] Cookson, N.A.*, Mather, W.H.*, Danino, T., Mondragon-Palomino, O., Williams, R.J., Tsimring, L.S., and Hasty, J. Queueing up for enzymatic processing: Correlated signaling through coupled degradation. Molecular Systems Biology 7, a. 561 (2011).

[10] Jin, M., Errede, B., Behar, M., Mather, W.H., Nayak, S., Hasty, J., Dohlman, H.G., and Elston, T.C. Yeast dynamically modify their environment to achieve better mating efficiency. Science Signaling 4, ra54 (2011).

[9] Mather, W.H., Hasty, J., Tsimring, L.S., Williams, R.J. Factorized time-dependent distributions for certain multiclass queueing networks and an application to enzymatic processing networks. Queueing Systems 69, 313-328 (2011).

[8] Boyer D.*, Mather W.H.*, Mondragn-Palomino O., Orozco-Fuentes S., Danino T., Hasty J, Tsimring L.S. Buckling instability in ordered bacterial colonies. Physical Biology 8, 026008 (2011).

[7] Mather, W.H., Cookson, N.A., Hasty, J., Tsimring, L.S., Williams, R.J. Correlation Resonance Generated by Coupled Enzymatic Processing. Biophysical Journal 99, 3172–3181 (2010).

[6] Mather, W.H., Mondragon-Palomino, O. Danino, T., Hasty, J., Tsimring, L.S. Streaming Instability in Growing Cell Populations. Physical Review Letters 104, 208101 (2010).

[5] Mather, W., Bennett, M. R., Hasty, J. & Tsimring, L. S. Delay-induced degrade-and-fire oscillations in small genetic circuits. Physical Review Letters 102, 068105 (2009).

[4] Stricker, J. et al. A fast, robust and tunable synthetic gene oscillator. Nature 456, 516–519 (2008).

[3] Mather, W. H. & Fox, R. F. Kinesin’s biased stepping mechanism: Amplification of neck linker zippering. Biophysical Journal 91, 2416–2426 (2006).

[2] Mather, W. H. & Fox, R. F. Universal turning point behavior for Gaussian-Klauder states and an application for maximally eccentric Rydberg atoms. Physical Review A 74 (2006).

[1] Mather, W. H. & Fox, R. F. Coherent-state analysis of the quantum bouncing ball. Physical Review A 73 (2006).

(* co-lead)

Thesis: Mather, W. Rectified Brownian Motion in Biology. Ph.D. thesis. Georgia Institute of Technology (2003).

E-Book reference: Some work on polymer models found in Mysterium Tremendum Part 3: http://www.fefox.com/ARTICLES/Part3.pdf