Matt Bennett
Postdoctoral Fellow
NIH Kirschstein Fellow
Email:
mbennett AT ucsd.edu
Phone:
858.822.3857
My CV and
Research Statement.
Education
Ph.D., Physics, Georgia Tech (2006)
B.S., Physics, Georgia Tech (2000)
Research Interests
My research generally spans the boundary between experimental and theoretical molecular systems biology. In particular, I am interested in the dynamics of gene regulation - from small scale interactions such as transcription and translation, to the large scale dynamics of gene regulatory networks. I use a hybrid experimental and computational approach to uncover the underlying design principles governing native gene networks and to use these concepts to design novel synthetic circuits.
Publications
- M. R. Bennett and J. Hasty,
“Overpowering the component problem,”
Nat. Biotech. 27, 450-451 (2009).
[PDF]
- W. Mather, M. R. Bennett, J. Hasty and L. S. Tsimring,
“Delay-induced degrade-and-fire oscillations in small
genetic circuits,”
Phys. Rev. Lett. 102, 068105 (2009).
[PDF]
- A.
Handel and M. R. Bennett, “Surviving the bottleneck:
Transmission mutants and the evolution of microbial populations,”
Genetics 180, 2193-2200 (2008).
[PDF]
- J.
Stricker, S. Cookson, M. R. Bennett, W. H. Mather, L. S. Tsimring and J. Hasty,
“A fast, robust and tunable synthetic gene oscillator,”
Nature 456, 516-519 (2008).
[PDF]
- M.
R. Bennett, W. L. Pang, N. A. Ostroff, B. L. Baumgartner, S. Nayak, L. S. Tsimring and J. Hasty, “Metabolic gene regulation in a dynamically changing environment,”
Nature 454, 1119-1122 (2008).
[PDF]
- M.
R. Bennett and J. Hasty, “Genome rewired,”
Nature 452, 824-825 (2008).
[PDF]
- T.
Lu, T. Shen, M. R. Bennett, P. G. Wolynes and J. Hasty, “Phenotypic variability of growing
cellular populations,”
Proc. Natl. Acad. Sci. USA 104, 18982-18987 (2007).
[PDF]
- C.
Grilly, J. Stricker, W. L. Pang, M. R. Bennett and J. Hasty, “A
synthetic gene network for tuning protein degradation in
Saccharomyces cerevisiae,” Mol. Sys. Bio. 3, 127 (2007).
[PDF]
- M.
R. Bennett, D. Volfson, L. Tsimring and J. Hasty, “Transient
dynamics of genetic regulatory networks,” Biophys. J. 92,
3501-3512 (2007). [PDF]
- M.
R. Bennett and J. Hasty, “A DNA methylation-based switch generates
bistable gene expression,”
Nat. Genet. 39, 146-147 (2007).
[PDF]
- M.
R. Bennett and K. Wiesenfeld, “Towards a unified rate theory
of stochastic resonance,” Fluct. Noise Lett. 6,
L405-L413 (2006). [Preprint]
- M.
R. Bennett, “Synchronization and Signal Enhancement in
Nonlinear and Stochastic Systems,” Ph.D. Dissertation,
Georgia Tech (2006). [PDF]
- J.
F. Lindner, M. Bennett and K. Wiesenfeld, “Potential energy
landscape and finite-state models of array-enhanced stochastic
resonance,” Phys. Rev. E 73, 031107 (2006).
[PDF]
- J.
F. Lindner, M. Bennett and K. Wiesenfeld, “Stochastic
resonance in the mechanoelectrical transduction of hair cells,”
Phys. Rev. E 72, 051911 (2005) and Virtual
Journal of Biological Physics Research 10, no. 10 (2005).
[PDF]
- M.
Bennett, K. Wiesenfeld and F. Jaramillo, “Stochastic
resonance in hair cells,” Fluct. Noise Lett. 4,
L1-L10 (2004). [PDF]
- M.
Bennett and K. Wiesenfeld, “Averaged equations for
distributed Josephson junction arrays,” Physica D 192,
196-214 (2004). [Preprint]
- M.
Bennett, M. F. Schatz, H. Rockwood and K. Wiesenfeld, “Huygens’
clocks,” Proc. Roy. Soc. London A 458,
563-579 (2002). [PDF]
